Research on the use of genetic information to improve cardiovascular risk estimation in individuals at intermediate risk can be carried out as a second step or in parallel, and further studies to develop new ways to include this information in risk functions, to evaluate its cost-effectiveness, and to explore the ethical issues are also warranted. Disability-adjusted life years DALYs for diseases and injuries in 21 regions, — a systematic analysis for the Global Burden of Disease Study Lluis-Ganella C.
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Genetic link to heart disease
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Nat Genet. Genetic linkage studies. Kathiresan S, Srivastava D. Genetics of human cardiovascular disease. Systolic and diastolic blood pressure lowering as determinants of cardiovascular outcome. The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Mutation of MEF2A in an inherited disorder with features of coronary artery disease. A third major locus for autosomal dominant hypercholesterolemia maps to 1p Am J Hum Genet.
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Candidate-gene approaches for studying complex genetic traits: practical considerations. How to use an article about genetic association. C: What are the results and will they help me in caring for my patients? Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Five years of GWAS discovery. The International HapMap Consortium.
A haplotype map of the human genome. Arking DE, Chakravarti A. Understanding cardiovascular disease through the lens of genome-wide association studies. Trends Genet. PLINK: a tool set for whole-genome association and population-based linkage analyses.
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Roberts R, Stewart AF. Genes and coronary artery disease: where are we? Finding the missing heritability of complex diseases. A catalog of published genome-wide association studies. Marian AJ. Trends Cardiovasc Med. Almasy L. The role of phenotype in gene discovery in the whole genome sequencing era.
Hum Genet. A common variant on chromosome 9p21 affects the risk of myocardial infarction. A common allele on chromosome 9 associated with coronary heart disease. Wellcome Trust Case Control Consortium. Genome-wide association study of 14, cases of seven common diseases and 3, shared controls. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
Association analyses of , individuals reveal 18 new loci associated with body mass index.
Risk factors, biochemical markers, and genetic polymorphisms in early coronary artery disease
Biological, clinical and population relevance of 95 loci for blood lipids. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia.
The PCSK9 decade. J Lipid Res. Atorvastatin with or without an antibody to PCSK9 in primary hypercholesterolemia. N Engl J Med. McPherson R. Chromosome 9p Given the high prevalence of this disease in India, the presence of environmental triggers and genetic variation, it would be prudent to conduct multi-ethnic large-scale studies in India, representing the subcontinent as a whole-there have been a very limited number of molecular genetic studies on Indian populations.
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Current Cardiovascular Risk Reports. Journal of Clinical and Diagnostic Research. Users online: Home Subscribe Feedback Login. Latest Articles. Article Submission. J Postgrad Med ; Figure 1: Pie diagram representing total NCD deaths in Table 1: Classification of cardiovascular diseases conditions Click here to view. Figure 2: Major risk factors of coronary artery disease Click here to view. Figure 3: Bar diagram representing number of coronary artery disease candidate genes studied for each metabolism Click here to view.
Figure 4: Bar diagram representing relative proportion of studies showing significant association for each candidate gene of CAD Click here to view. Table 2: List of candidate genes of coronary artery disease with chromosomal loci and their functional metabolism Click here to view.